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RECEPTORS, DEATH DOMAIN
Descriptors Found:
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DeCS
Descriptor
English
:
Receptors, Death Domain
Descriptor
Spanish
:
Receptores de Muerte Celular
Descriptor
Portuguese
:
Receptores de Morte Celular
Synonyms
English
:
Death Domain Receptors
Tree Number:
D12.776.543.750.073
Definition
English
:
A
family
of cell surface receptors that signal via a conserved domain that extends into the cell
CYTOPLASM
. The conserved domain is referred to as a
death
domain due to the fact that many of these receptors are involved in signaling
APOPTOSIS
. Several
DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS
can bind to the
death
domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as
CASPASES.
See Related
English
:
Receptors, Tumor Necrosis Factor
History Note
English
:
2007
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
52336
Unique Identifier:
D053218
Occurrence in VHL
:
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